Sette A, Wentworth P, Grey H M
Cytel, San Diego, California.
Curr Opin Biotechnol. 1991 Dec;2(6):877-81. doi: 10.1016/s0958-1669(05)80125-9.
Peptides that bind with high affinity to major histocompatibility complex molecules could represent useful tools in treating class II-associated autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and multiple sclerosis. Although the concept has been validated in experiments with both purified receptor systems in vitro and cellular systems in vivo, many challenging problems need to be resolved before efficacious therapeutic agents are obtained.
与主要组织相容性复合体分子具有高亲和力结合的肽，可能是治疗类风湿性关节炎、1型糖尿病和多发性硬化症等II类相关自身免疫性疾病的有用工具。尽管这一概念已在体外纯化受体系统和体内细胞系统的实验中得到验证，但在获得有效的治疗药物之前，仍有许多具有挑战性的问题需要解决。
