Day M J, Penhale W J
Vet Res Commun. 1987;11(2):119-32. doi: 10.1007/BF00344944.
The organization and biology of the Major Histocompatibility Complexes (MHC) of man (HLA) and dog (DLA) are reviewed, and a summary is presented of laboratory techniques used to define allotypes. The nomenclature of this field and the mechanisms of disease association with the MHC are discussed. Currently recognized HLA-disease associations are enumerated, with emphasis on the value of the complement C4 marker. DLA-disease association studies into autoimmune disease, allergy and neoplasia are reviewed.
本文综述了人类（HLA）和犬类（DLA）主要组织相容性复合体（MHC）的组织学和生物学，并总结了用于定义同种异型的实验室技术。讨论了该领域的命名法以及与MHC相关的疾病机制。列举了目前公认的HLA与疾病的关联，重点强调了补体C4标志物的价值。综述了DLA与自身免疫性疾病、过敏和肿瘤的疾病关联研究。
