用于治疗干预的反义寡核苷酸。

Antisense oligonucleotides for therapeutic intervention.

作者信息

Eck S L, Nabel G J

机构信息

Howard Hughes Medical Institute, University of Michigan Medical Center, Department of Internal Medicine, Ann Arbor 48109-0650.

出版信息

Curr Opin Biotechnol. 1991 Dec;2(6):897-904. doi: 10.1016/s0958-1669(05)80128-4.

DOI:10.1016/s0958-1669(05)80128-4

PMID:1367966

Abstract

Advances have been made in defining the best target sequences for use in antisense oligonucleotide technology, and new chemical derivatives of oligonucleotides are being investigated. Although the potential use of antisense oligonucleotide agents in the treatment of neoplastic, viral and parasitic diseases continues to be explored, they are not yet suitable for administration to humans for reasons that are discussed.

摘要

在确定反义寡核苷酸技术中最佳靶序列方面已取得进展，并且正在研究寡核苷酸的新化学衍生物。尽管仍在探索反义寡核苷酸药物在治疗肿瘤、病毒和寄生虫疾病方面的潜在用途，但由于文中所讨论的原因，它们目前还不适合用于人体给药。