Agrawal S, Zhao Q
Hybridon Inc, Cambridge, MA 02139, USA.
Curr Opin Chem Biol. 1998 Aug;2(4):519-28. doi: 10.1016/s1367-5931(98)80129-4.
The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway. Questions regarding the specificity of action and side effects of antisense phosphorothioate oligonucleotides have arisen simultaneously.
在过去十年中，反义疗法领域引起了极大的关注。最近出现了大量文献，其中声称涉及反义机制，并且多项人体临床试验正在进行中。与此同时，关于反义硫代磷酸酯寡核苷酸的作用特异性和副作用的问题也出现了。
