Reddy Pradeep, Najundaswamy Shakuntala, Mehta Rajeev, Petrova Anna, Hegyi Thomas
Division of Neonatology, Department of Pediatrics, UMDNJ-Robert Wood Johnson Medical School, Saint Peter's University Hospital, 254 Easton Avenue, New Brunswick, NJ 08901, USA.
J Perinatol. 2003 Sep;23(6):507-8. doi: 10.1038/sj.jp.7210943.
Tin-mesoporphyrin (SnMP) is a competitive inhibitor of microsomal heme oxygenase (the rate-limiting enzyme in the heme catabolic pathway). It was administered as a single intramuscular dose at 46 hours of life to a very-low-birth-weight infant with severe hemolytic hyperbilirubinemia who had been awaiting an exchange transfusion. This case documents the effective elimination of the need for an exchange transfusion in a very-low-birth-weight infant and is a confirmation of the experience of others for the use of SnMP in reducing bilirubin production.
锡-中卟啉（SnMP）是微粒体血红素加氧酶（血红素分解代谢途径中的限速酶）的竞争性抑制剂。在一名极低出生体重且患有严重溶血性高胆红素血症、一直在等待换血治疗的婴儿出生46小时后，给予其单次肌肉注射锡-中卟啉。该病例证明了在极低出生体重婴儿中有效消除了换血治疗的必要性，也证实了其他人使用锡-中卟啉减少胆红素生成的经验。
