Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Semin Fetal Neonatal Med. 2010 Jun;15(3):164-8. doi: 10.1016/j.siny.2009.11.004. Epub 2009 Dec 16.
Neonatal jaundice in the first week of life is a common problem in newborns. It is due to an imbalance of bilirubin production and its elimination, which can lead to significantly elevated levels of circulating bilirubin or hyperbilirubinemia. Use of phototherapy and/or exchange transfusion are the current modes for treating neonatal hyperbilirubinemia and preventing any neurologic damage. These strategies, however, only remove bilirubin that has already been formed. Preventing the production of excess bilirubin may be a more logical approach. Synthetic heme analogs, metalloporphyrins, are competitive inhibitors of heme oxygenase, the rate-limiting enzyme in bilirubin production, and their use has been proposed as an attractive alternative strategy for preventing or treating severe hyperbilirubinemia.
新生儿在出生后的第一周内出现黄疸是一种常见的现象。这是由于胆红素的产生和排泄失衡所导致的，可能会导致循环胆红素水平显著升高或高胆红素血症。目前，光疗和/或换血是治疗新生儿高胆红素血症和预防任何神经损伤的主要手段。然而，这些策略只能去除已经形成的胆红素。预防过多胆红素的产生可能是一种更合理的方法。人工合成血红素类似物，金属卟啉，是血红素加氧酶的竞争性抑制剂，血红素加氧酶是胆红素生成的限速酶，因此，它们的使用被提议作为一种有吸引力的替代策略，用于预防或治疗严重的高胆红素血症。
