• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一些新型1,3,4-恶二唑衍生物的合成及其抗炎活性

Synthesis and anti-inflammatory activity of some novel 1,3,4-oxadiazole derivatives.

作者信息

Abd el-Samii Z K

机构信息

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Great Al-Fateh University, Tripoli, Libya.

出版信息

J Chem Technol Biotechnol. 1992;53(2):143-6. doi: 10.1002/jctb.280530206.

DOI:10.1002/jctb.280530206
PMID:1368010
Abstract

Some novel 1,3,4-oxadiazoline and 1,3,4-oxadiazole derivatives have been synthesized from 3-hydroxy-5,6-diphenyl-1,2,4-triazine. Illucidation of the structures of the isolated products has been proved in the light of their elemental analysis, spectroscopic data and unambiguous synthesis in certain cases. Some derivatives have shown promising anti-inflammatory activity in comparison to phenylbutazone.

摘要

一些新型的1,3,4-恶二唑啉和1,3,4-恶二唑衍生物已由3-羟基-5,6-二苯基-1,2,4-三嗪合成。根据元素分析、光谱数据以及某些情况下明确的合成方法，已证实了分离产物的结构。与保泰松相比，一些衍生物显示出有前景的抗炎活性。

相似文献

1
Synthesis and anti-inflammatory activity of some novel 1,3,4-oxadiazole derivatives.一些新型1,3,4-恶二唑衍生物的合成及其抗炎活性
J Chem Technol Biotechnol. 1992;53(2):143-6. doi: 10.1002/jctb.280530206.
2
Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives.5-氨基取代 1,2,4-噁二唑衍生物的方便合成及生物学特性。
Eur J Med Chem. 2010 Dec;45(12):5635-45. doi: 10.1016/j.ejmech.2010.09.016. Epub 2010 Sep 17.
3
Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: synthesis and their anti-inflammatory and analgesic activities.基于芳酰丙酸的2,5-二取代-1,3,4-恶二唑：合成及其抗炎和镇痛活性。
Eur J Med Chem. 2009 Jun;44(6):2372-8. doi: 10.1016/j.ejmech.2008.09.005. Epub 2008 Sep 16.
4
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.含5-取代-1,3,4-恶二唑的5,6-二苯基-1,2,4-三嗪-3(2H)-酮衍生物作为潜在抗炎和镇痛剂的合成、表征、评价及分子动力学研究
Eur J Med Chem. 2015 Aug 28;101:81-95. doi: 10.1016/j.ejmech.2015.06.020. Epub 2015 Jun 11.
5
Synthesis of some novel oxadiazole and oxadiazoline analogues for their antiinflammatory activity.一些新型恶二唑和恶二唑啉类似物的抗炎活性合成
Yakugaku Zasshi. 2007 Oct;127(10):1757-64. doi: 10.1248/yakushi.127.1757.
6
Synthesis and biological screening of 5-(alkyl(1H-indol-3-yl))-2-(substituted)-1,3,4-oxadiazoles as antiproliferative and anti-inflammatory agents.5-(烷基(1H-吲哚-3-基))-2-(取代)-1,3,4-恶二唑的合成及作为抗增殖和抗炎剂的生物筛选。
Eur J Med Chem. 2013 Aug;66:91-100. doi: 10.1016/j.ejmech.2013.05.024. Epub 2013 May 28.
7
Design, synthesis and QSAR studies on a series of 2, 5-disubstituted- 1,3,4-oxadiazole derivatives of diclofenac and naproxen for analgesic and anti-inflammatory activity.双氯芬酸和萘普生系列2,5-二取代-1,3,4-恶二唑衍生物的镇痛和抗炎活性的设计、合成及定量构效关系研究
Med Chem. 2015;11(8):753-63. doi: 10.2174/1573406411666150519112037.
8
Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: Synthesis, in-vivo, in-vitro and in-silico analysis.吲哚功能化吡唑和恶二唑类化合物作为抗炎剂的研究：合成、体内、体外和计算分析。
Bioorg Chem. 2021 Sep;114:105068. doi: 10.1016/j.bioorg.2021.105068. Epub 2021 Jun 8.
9
Synthesis of some new 2-(6-methoxy-2-naphthyl)- 5-aryl-1,3,4-oxadiazoles as possible non-steroidal anti-inflammatory and analgesic agents.一些新型2-(6-甲氧基-2-萘基)-5-芳基-1,3,4-恶二唑作为潜在非甾体抗炎和镇痛药的合成
Arch Pharm (Weinheim). 2005 Aug;338(8):373-7. doi: 10.1002/ardp.200500974.
10
Synthesis of novel of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study.新型 2,5-二取代 1,3,4-恶二唑衍生物的合成及其抗炎、抗氧化活性评价和分子对接研究。
Bioorg Med Chem Lett. 2020 Jun 15;30(12):127136. doi: 10.1016/j.bmcl.2020.127136. Epub 2020 Mar 25.

引用本文的文献

1
3-Methyl-sulfanyl-5-phenyl-1,2,4-triazine.3-甲基硫烷基-5-苯基-1,2,4-三嗪
Acta Crystallogr Sect E Struct Rep Online. 2014 May 31;70(Pt 6):o720. doi: 10.1107/S1600536814011830. eCollection 2014 Jun 1.
2
Design and Microwave-assisted Synthesis of 1,3,4-Oxadiazole Derivatives for Analgesic and Anti-inflammatory Activity.用于镇痛和抗炎活性的1,3,4-恶二唑衍生物的设计与微波辅助合成
J Young Pharm. 2012 Jan;4(1):33-7. doi: 10.4103/0975-1483.93576.