一些新型1,3,4-恶二唑衍生物的合成及其抗炎活性
Synthesis and anti-inflammatory activity of some novel 1,3,4-oxadiazole derivatives.
作者信息
Abd el-Samii Z K
机构信息
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Great Al-Fateh University, Tripoli, Libya.
出版信息
J Chem Technol Biotechnol. 1992;53(2):143-6. doi: 10.1002/jctb.280530206.
PMID:1368010
Abstract
Some novel 1,3,4-oxadiazoline and 1,3,4-oxadiazole derivatives have been synthesized from 3-hydroxy-5,6-diphenyl-1,2,4-triazine. Illucidation of the structures of the isolated products has been proved in the light of their elemental analysis, spectroscopic data and unambiguous synthesis in certain cases. Some derivatives have shown promising anti-inflammatory activity in comparison to phenylbutazone.
摘要
一些新型的1,3,4-恶二唑啉和1,3,4-恶二唑衍生物已由3-羟基-5,6-二苯基-1,2,4-三嗪合成。根据元素分析、光谱数据以及某些情况下明确的合成方法，已证实了分离产物的结构。与保泰松相比，一些衍生物显示出有前景的抗炎活性。
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