Kökçü Arif, Turhan Elif, Cetinkaya Mehmet B, Yanik Filiz, Alper Tayfun, Malatyalioğlu Erdal
Department of Obstetrics and Gynecology, School of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
Arch Gynecol Obstet. 2004 Dec;270(4):255-9. doi: 10.1007/s00404-003-0557-y. Epub 2003 Sep 12.
In this prospective clinical single blind study, we aimed to investigate whether day 3 serum inhibin B levels in women with polycystic ovarian syndrome(PCOS) are of predictive value for the estimation of the ovarian response to gonadotropins.
Ovulation induction with low dose step-up gonadotropin protocol, starting with 75 IU/day, was performed for 30 cycles on 25 patients with PCOS. Day 3 serum inhibin B, follicle-stimulating hormone(FSH) and estradiol, and midluteal serum progesterone levels were measured during each cycle. The correlations between day 3 inhibin B levels and day 3 FSH, day 3 estradiol and midluteal progesterone measurements, as well as the amount of gonadotropin required to provide an ovulatory cycle were investigated.
Five (27.8%) out of 18 cycles with day 3 inhibin levels <50.0 pg/ml; and 11 (91.7%) out of 12 cycles with levels > or = 50.0 pg/ml were ovulatory (chi(2)=9.38, p<0.01). Moreover, day 3 inhibin B levels had statistically significant negative correlation with the gonadotropin used; and significant positive correlation with the midluteal progesterone levels (p<0.05). There wasn't any significant relation between day 3 FSH and estradiol levels with the gonadotropin used and progesterone levels.
It has been observed that as day 3 serum inhibin B levels increased in women with PCOS, the ovulatory response to gonadotropins and the rate of ovulatory cycles increased significantly.
在这项前瞻性临床单盲研究中，我们旨在调查多囊卵巢综合征（PCOS）女性第3天血清抑制素B水平对于评估卵巢对促性腺激素反应是否具有预测价值。
对25例PCOS患者进行了30个周期的低剂量递增促性腺激素方案诱导排卵，起始剂量为75IU/天。在每个周期中测量第3天血清抑制素B、促卵泡生成素（FSH）和雌二醇，以及黄体中期血清孕酮水平。研究了第3天抑制素B水平与第3天FSH、第3天雌二醇和黄体中期孕酮测量值之间的相关性，以及诱导排卵周期所需的促性腺激素量。
第3天抑制素水平<50.0pg/ml的18个周期中有5个（27.8%）发生排卵；第3天抑制素水平≥50.0pg/ml的12个周期中有11个（91.7%）发生排卵（χ2=9.38，p<0.01）。此外，第3天抑制素B水平与所用促性腺激素呈显著负相关；与黄体中期孕酮水平呈显著正相关（p<0.05）。第3天FSH和雌二醇水平与所用促性腺激素及孕酮水平之间无显著关系。
观察到PCOS女性第3天血清抑制素B水平升高时，对促性腺激素的排卵反应及排卵周期率显著增加。
