Torgac Mustafa, Kokcu Arif, Cetinkaya Mehmet B, Alper Tayfun, Malatyalioglu Erdal
Department of Obstetrics and Gynecology, School of Medicine, University of Ondokuz Mayis, 55070 Samsun, Turkey.
Gynecol Endocrinol. 2005 Jun;20(6):322-6. doi: 10.1080/09513590500098125.
In the present study we aimed to investigate whether basal inhibin A and B levels in women with polycystic ovary syndrome (PCOS) would be used in diagnosis of the condition. Forty women with PCOS and 40 women with normal cycles (control group) were evaluated. There was no statistically significant difference in mean age and mean body mass index between the two groups (p > 0.05). Serum levels of inhibin A and B, follicle-stimulating hormone (FSH), luteinizing hormone and total testosterone, and total ovarian volume, were determined in the PCOS group and the control group on day 3. In the PCOS group, total follicle number was obtained by counting follicles of diameter > or =2 mm in both ovaries. Results were evaluated using Student's t test, Pearson correlation and regression tests. There was no significant difference in mean basal inhibin A or inhibin B levels between the two groups. Basal inhibin B levels showed a statistically significant negative correlation with basal FSH levels and a positive correlation with total follicle number in the PCOS group (p < 0.05 and p < 0.01, respectively). We conclude that basal inhibin A or B levels cannot be used in the diagnosis of PCOS.
在本研究中，我们旨在调查多囊卵巢综合征（PCOS）女性的基础抑制素A和B水平是否可用于该疾病的诊断。对40名PCOS女性和40名月经周期正常的女性（对照组）进行了评估。两组之间的平均年龄和平均体重指数无统计学显著差异（p>0.05）。在第3天测定PCOS组和对照组的血清抑制素A和B、促卵泡生成素（FSH）、促黄体生成素和总睾酮水平，以及卵巢总体积。在PCOS组中，通过计数双侧卵巢中直径≥2mm的卵泡来获得卵泡总数。使用学生t检验、Pearson相关性和回归检验对结果进行评估。两组之间的基础抑制素A或抑制素B平均水平无显著差异。在PCOS组中，基础抑制素B水平与基础FSH水平呈统计学显著负相关，与卵泡总数呈正相关（分别为p<0.05和p<0.01）。我们得出结论，基础抑制素A或B水平不能用于PCOS的诊断。
