Bouquet Cédric A, Bonnaud Véronique, Gil Roger
LAPMH, EA 2253, University of Poitiers, Poitiers, France.
J Clin Exp Neuropsychol. 2003 Sep;25(6):751-60. doi: 10.1076/jcen.25.6.751.16478.
The study explored executive dysfunction in Parkinson's disease (PD) by using the Hayling test (Burgess & Shallice, 1996) and verbal fluency tasks (VFTs). PD patients showed longer response latencies than controls in both parts of the Hayling test (Section A/automatic and Section B/inhibition). Patients and controls did not differ in the proportion of errors or number of responses that revealed the use of strategies. PD patients also showed verbal fluency deficits in semantic, phonemic, and alternating fluency tasks. These impairments on tests known to be sensitive to frontal lobe dysfunction confirm executive or Supervisory Attentional System (Norman & Shallice, 1986) deficits and further indicate suppression skills impairments in PD.
该研究通过使用海林测试（Burgess和Shallice，1996年）及语言流畅性任务（VFTs），探究了帕金森病（PD）中的执行功能障碍。在海林测试的两个部分（A部分/自动部分和B部分/抑制部分）中，帕金森病患者的反应潜伏期均长于对照组。患者和对照组在揭示策略使用情况的错误比例或反应数量上没有差异。帕金森病患者在语义、音素和交替流畅性任务中也表现出语言流畅性缺陷。这些在已知对额叶功能障碍敏感的测试中的损伤证实了执行功能或监督注意系统（Norman和Shallice，1986年）的缺陷，并进一步表明帕金森病患者存在抑制技能损伤。
