School of Health and Rehabilitation Sciences, Queensland Aphasia Research Centre and UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.
NHMRC Centre of Research Excellence in Aphasia Recovery and Rehabilitation, Melbourne, VIC, Australia.
Neuropsychol Rev. 2021 Sep;31(3):472-494. doi: 10.1007/s11065-021-09481-9. Epub 2021 May 12.
The role of corticostriatal circuits in language functions is unclear. In this review, we consider evidence from language learning, syntax, and controlled language production and comprehension tasks that implicate various corticostriatal circuits. Converging evidence from neuroimaging in healthy individuals, studies in populations with subcortical dysfunction, pharmacological studies, and brain stimulation suggests a domain-general regulatory role of corticostriatal systems in language operations. The role of corticostriatal systems in language operations identified in this review is likely to reflect a broader function of the striatum in responding to uncertainty and conflict which demands selection, sequencing, and cognitive control. We argue that this role is dynamic and varies depending on the degree and form of cognitive control required, which in turn will recruit particular corticostriatal circuits and components organised in a cognitive hierarchy.
皮质纹状体回路在语言功能中的作用尚不清楚。在这篇综述中，我们考虑了来自语言学习、语法以及受控语言产生和理解任务的证据，这些证据暗示了各种皮质纹状体回路的作用。来自健康个体的神经影像学研究、皮质下功能障碍人群的研究、药理学研究和脑刺激研究的一致证据表明，皮质纹状体系统在语言操作中具有普遍的调节作用。本综述中确定的皮质纹状体系统在语言操作中的作用可能反映了纹状体在应对不确定性和冲突方面的更广泛功能，这需要选择、排序和认知控制。我们认为，这种作用是动态的，并且取决于所需认知控制的程度和形式，这反过来又会招募特定的皮质纹状体回路和以认知层次组织的组件。
