Yildiran Alişan, Kücüködük Sükrü, Saniç Ahmet, Belet Nurşen, Güvenli Abdullah
Department of Pediatrics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Am J Perinatol. 2003 Jul;20(5):269-71. doi: 10.1055/s-2003-42337.
Trichosporon asahii (T. asahii) is an uncommon cause of yeast infection in preterms. We present a 27-week gestational age female with clinical evidence of sepsis, such as patchy infiltrations on chest roentgenogram, and yeast growing in urine and blood cultures. Conventional amphotericin B was empirically added in a dose of 0.5 mg/kg, q8h to standard protocol of the neonatal intensive care unit. Dose of the drug was induced to 1 mg/kg because the patient had not improved when the organism was identified as T. asahii on the pretreatment urine and blood cultures. Both cultures were clear on the 10th day of amphotericin B therapy and treatment was ceased on the 21st day. The patient was healthy when discharged. Trichosporon infections in neonates have been almost uniformly fatal. Most strains of T. asahii may be confused with Candida spp. on initial culture examinations. Therefore, delays in appropriate treatment may occur.
阿萨希毛孢子菌（T. asahii）是早产儿酵母菌感染的罕见病因。我们报告一例孕27周的女性，有败血症的临床证据，如胸部X光片上的斑片状浸润，尿液和血培养中有酵母菌生长。按照新生儿重症监护病房的标准方案，经验性地添加常规两性霉素B，剂量为0.5mg/kg，每8小时一次。当在治疗前的尿液和血培养中鉴定出该病原体为阿萨希毛孢子菌时，由于患者病情未改善，药物剂量增至1mg/kg。两性霉素B治疗第10天时，两次培养均转阴，第21天停止治疗。出院时患者健康。新生儿毛孢子菌感染几乎无一例外是致命的。在初次培养检查时，大多数阿萨希毛孢子菌菌株可能与念珠菌属混淆。因此，可能会出现适当治疗延迟的情况。
