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本文引用的文献

1
Development and clinical application of a panfungal PCR assay to detect and identify fungal DNA in tissue specimens.一种用于检测和鉴定组织标本中真菌DNA的泛真菌PCR检测方法的开发与临床应用。
J Clin Microbiol. 2007 Feb;45(2):380-5. doi: 10.1128/JCM.01862-06. Epub 2006 Nov 22.
2
Voriconazole therapeutic drug monitoring.伏立康唑治疗药物监测。
Antimicrob Agents Chemother. 2006 Apr;50(4):1570-2. doi: 10.1128/AAC.50.4.1570-1572.2006.
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Trichosporon asahii fatal infection in a non-neutropenic patient after orthotopic liver transplantation.原位肝移植术后非中性粒细胞减少患者发生的阿萨希毛孢子菌致死性感染。
Transpl Infect Dis. 2005 Sep-Dec;7(3-4):162-5. doi: 10.1111/j.1399-3062.2005.00104.x.
4
Fungemia due to Trichosporon asahii in a neutropenic child refractory to amphotericin B: clearance with voriconazole.一名中性粒细胞减少的儿童因阿萨希毛孢子菌引起的真菌血症，对两性霉素B耐药：伏立康唑清除真菌。
J Pediatr Hematol Oncol. 2005 May;27(5):283-5. doi: 10.1097/01.mph.0000164865.70522.d7.
5
Trichosporon asahii infection treated with caspofungin combined with liposomal amphotericin B.用卡泊芬净联合两性霉素B脂质体治疗阿萨希毛孢子菌感染。
J Antimicrob Chemother. 2004 Aug;54(2):575-7. doi: 10.1093/jac/dkh337. Epub 2004 Jul 1.
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Pharmacokinetics and safety of intravenous voriconazole in children after single- or multiple-dose administration.单剂量或多剂量静脉注射伏立康唑在儿童中的药代动力学及安全性
Antimicrob Agents Chemother. 2004 Jun;48(6):2166-72. doi: 10.1128/AAC.48.6.2166-2172.2004.
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Disseminated Trichosporon asahii infection in a preterm.早产儿播散性阿萨希毛孢子菌感染
Am J Perinatol. 2003 Jul;20(5):269-71. doi: 10.1055/s-2003-42337.
8
Use of voriconazole to successfully treat disseminated Trichosporon asahii infection in a patient with acute myeloid leukaemia.伏立康唑成功治疗1例急性髓系白血病患者播散性阿萨希毛孢子菌感染
Eur J Clin Microbiol Infect Dis. 2002 Dec;21(12):892-6. doi: 10.1007/s10096-002-0841-y. Epub 2002 Nov 1.
9
In vitro antifungal susceptibilities of Trichosporon species.丝孢酵母属菌种的体外抗真菌药敏性
Antimicrob Agents Chemother. 2002 Apr;46(4):1144-6. doi: 10.1128/AAC.46.4.1144-1146.2002.
10
Trichosporon beigelii, an emerging pathogen resistant to amphotericin B.白吉利丝孢酵母，一种对两性霉素B耐药的新出现病原体。
J Clin Microbiol. 1990 Jul;28(7):1616-22. doi: 10.1128/jcm.28.7.1616-1622.1990.

儿童急性淋巴细胞白血病合并致命性播散性近平滑念珠菌感染

Fatal disseminated Trichosporon asahii infection in a child with acute lymphoblastic leukemia.

机构信息

Infectious Diseases Division, Department of Pediatrics, CHU Sainte Justine, Université de Montréal, Montreal, Quebec.

出版信息

Can J Infect Dis Med Microbiol. 2008 Mar;19(2):203-5. doi: 10.1155/2008/787689.

DOI:10.1155/2008/787689
PMID:19352453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2605863/
Abstract

Few cases of Trichosporon species infection have been reported in children. The present report describes a case of fatal disseminated Trichosporon asahii infection in a child treated for relapsed leukemia. Voriconazole has previously shown promising activity in vitro, and has been used successfully in the treatment of T asahii infections. The patient died five days after voriconazole treatment was started, and the autopsy revealed widespread systemic dissemination to all organs.

摘要

鲜有关于毛孢子菌属感染的儿童病例报道。本报告描述了一例复发白血病患儿罹患致命性播散性近平滑毛孢子菌感染的病例。伏立康唑在体外显示出良好的活性，并且已成功用于治疗 T 毛孢子菌感染。该患者在开始伏立康唑治疗后 5 天死亡，尸检显示所有器官均广泛全身播散。