Kost J, Langer R
Department of Chemical Engineering, Ben-Gurion University, Beer-Sheva, Israel.
Trends Biotechnol. 1992 Apr;10(4):127-31. doi: 10.1016/0167-7799(92)90194-z.
The ideal drug-delivery system should provide therapeutics in response to physiological requirements, having the capacity to 'sense' changes and alter the drug-release process accordingly. Such responsive controlled delivery systems are still at an experimental stage. This review focuses on two basic approaches: (1) externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and (2) self-regulated systems (utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).
理想的药物递送系统应根据生理需求提供治疗药物，能够“感知”变化并相应地改变药物释放过程。这种响应式控释系统仍处于实验阶段。本综述重点关注两种基本方法：（1）外部调节系统（利用磁性、超声、温度和电等触发因素），以及（2）自我调节系统（利用pH敏感聚合物、酶-底物反应、竞争性结合和抗体相互作用）。
