• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

由正常存在的化合物通过酶促反应形成拟精神病代谢物。

Enzymatic formation of psychotomimetic metabolites from normally occurring compounds.

作者信息

AXELROD J

出版信息

Science. 1961 Aug 4;134(3475):343. doi: 10.1126/science.134.3475.343.

DOI:10.1126/science.134.3475.343
PMID:13685339
Abstract

An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine.

摘要

已发现一种酶，它可将血清素和色胺甲基化为致幻代谢产物，即蟾毒色胺和N,N - 二甲基色胺。这种酶高度集中于兔肺中，并且还能将诸如酪胺、苯乙胺、三甲氧苯乙胺和多巴胺等苯乙胺衍生物甲基化。

相似文献

1
Enzymatic formation of psychotomimetic metabolites from normally occurring compounds.由正常存在的化合物通过酶促反应形成拟精神病代谢物。
Science. 1961 Aug 4;134(3475):343. doi: 10.1126/science.134.3475.343.
2
Further studies on the mode of action of psychotomimetic drugs: antagonism of the excitatory actions of 5-hydroxytryptamine by methylated derivatives of tryptamine.致幻药物作用模式的进一步研究：色胺甲基化衍生物对5-羟色胺兴奋作用的拮抗作用
Br J Pharmacol. 1974 Mar;50(3):345-54. doi: 10.1111/j.1476-5381.1974.tb09609.x.
3
A possible mechanism for the antischizophrenic action of chlorpromazine: inhibition of the formation of dimethyltryptamine by chlorpromazine metabolites.氯丙嗪抗精神分裂症作用的一种可能机制：氯丙嗪代谢产物对二甲基色胺形成的抑制作用。
Res Commun Chem Pathol Pharmacol. 1974 Jun;8(2):341-51.
4
A review of recent studies of the biosynthesis and excretion of hallucinogens formed by methylation of neurotransmitters or related substances.
Schizophr Bull. 1976;2(1):90-105. doi: 10.1093/schbul/2.1.90.
5
N, N-dimethyltryptamine: an endogenous hallucinogen.N，N-二甲基色胺：一种内源性致幻剂。
Int Rev Neurobiol. 1981;22:83-110. doi: 10.1016/s0074-7742(08)60291-3.
6
N,N-dimethyltryptamine--a possible relationship to schizophrenia?N，N-二甲基色胺——与精神分裂症可能存在的关系？
Adv Biochem Psychopharmacol. 1974;11(0):299-313.
7
Evidence for the absence of amine-N-methylation and O-methylation in indolethylamines with methyltetrahydrofolic acid-dependent N-methyltransferase.关于吲哚乙胺中不存在胺 - N - 甲基化和O - 甲基化以及依赖甲基四氢叶酸的N - 甲基转移酶的证据。
Res Commun Chem Pathol Pharmacol. 1974 Jul;8(3):535-42.
8
Quantitative assay of the N-methylated metabolites of tryptamine and serotonin by gas chromatography mass spectrometry as applied to the determination of lung indoleethylamine N-methyltransferase activity.通过气相色谱-质谱联用法定量测定色胺和血清素的N-甲基化代谢产物，用于测定肺吲哚乙胺N-甲基转移酶活性。
Biomed Mass Spectrom. 1978 Oct;5(10):596-600. doi: 10.1002/bms.1200051010.
9
Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues.血液和组织中具有潜在致幻性的5-羟色胺受体配体蟾蜍色胺和二甲基色胺。
Scand J Clin Lab Invest. 2005;65(3):189-99. doi: 10.1080/00365510510013604.
10
Effect of alpha-alkylated tryptamine derivatives on 5-hydroxytryptamine metabolism in vivo.α-烷基化色胺衍生物对体内5-羟色胺代谢的影响。
Br J Pharmacol Chemother. 1962 Aug;19(1):161-7. doi: 10.1111/j.1476-5381.1962.tb01437.x.

引用本文的文献

1
Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics.为什么N，N-二甲基色胺很重要：超越传统迷幻剂的独特特征和治疗潜力。
Front Psychiatry. 2024 Nov 6;15:1485337. doi: 10.3389/fpsyt.2024.1485337. eCollection 2024.
2
Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors.神经生物学对 N,N-二甲基色胺（DMT）及其单胺氧化酶（MAO）抑制作用的研究：从雅砻酒到 DMT 和 MAO 抑制剂的合成组合。
Cell Mol Life Sci. 2024 Sep 10;81(1):395. doi: 10.1007/s00018-024-05353-6.
3
Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.
S-腺苷甲硫氨酸（SAM）依赖性甲基转移酶相关疾病与遗传多态性的研究进展。
Mutat Res Rev Mutat Res. 2021 Jul-Dec;788:108396. doi: 10.1016/j.mrrev.2021.108396. Epub 2021 Oct 7.
4
Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans.分子和功能影像学研究致幻药物在动物和人类中的作用。
Molecules. 2021 Apr 22;26(9):2451. doi: 10.3390/molecules26092451.
5
Biosynthesis and synthetic biology of psychoactive natural products.精神活性天然产物的生物合成与合成生物学。
Chem Soc Rev. 2021 Jun 21;50(12):6950-7008. doi: 10.1039/d1cs00065a.
6
N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo.在致幻茶 ayahuasca 中发现的 N,N-二甲基色胺化合物，可调节体外和体内成年神经发生。
Transl Psychiatry. 2020 Sep 28;10(1):331. doi: 10.1038/s41398-020-01011-0.
7
Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants.人类吲哚（乙基）胺-N-甲基转移酶（hINMT）催化色胺、二甲基硫和二甲基硒的甲基化反应在还原条件下增强- 254C 和 254F 两种常见 hINMT 变体的比较。
PLoS One. 2019 Jul 16;14(7):e0219664. doi: 10.1371/journal.pone.0219664. eCollection 2019.
8
Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain.哺乳动物脑中 N,N-二甲基色胺（DMT）的生物合成和细胞外浓度。
Sci Rep. 2019 Jun 27;9(1):9333. doi: 10.1038/s41598-019-45812-w.
9
N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function.N，N-二甲基色胺（DMT），一种内源性致幻剂：确定其作用和功能的过去、现在及未来研究
Front Neurosci. 2018 Aug 6;12:536. doi: 10.3389/fnins.2018.00536. eCollection 2018.
10
Indolethylamine--methyltransferase Polymorphisms: Genetic and Biochemical Approaches for Study of Endogenous ,-dimethyltryptamine.吲哚乙胺 - 甲基转移酶多态性：研究内源性N，N - 二甲基色胺的遗传和生化方法。
Front Neurosci. 2018 Apr 23;12:232. doi: 10.3389/fnins.2018.00232. eCollection 2018.