Kjaer M, Thomsen M
Acta Pathol Microbiol Scand C. 1976 Oct;84C(5):403-13. doi: 10.1111/j.1699-0463.1976.tb00048.x.
Thirteen patients with renal carcinoma were examined for tumour-directed, cell-mediated hypersensitivity (TCMH) by means of the leucocyte migration technique, and for general immunocompetence (GIC) by means of quantitation of T- and B-cells in peripheral blood and studies of lymphocyte transformation in vitro using a panel of antigens and mitogens. Eight out of 13 patients had evidence of TCMH, six out of 13 had abnormal GIC. Any correlation between the presence of TCMH and normal/abnormal GIC was not found. There was a trend towards a positive correlation between the absence of distant metastases and evidence of TCMH. If both TCMH and GIC were considered, significant correlation between the presence of distant metastases, lack of TCMH and/or abnormal GIC was demonstrated. It is concluded that the defect TCMH usually found in patients with renal carcinoma and disseminated disease cannot be explained exclusively by defects in GIC.
采用白细胞迁移技术对13例肾癌患者进行肿瘤定向细胞介导超敏反应（TCMH）检测，通过对外周血T细胞和B细胞进行定量分析以及使用一组抗原和丝裂原进行体外淋巴细胞转化研究，对患者的一般免疫能力（GIC）进行检测。13例患者中有8例有TCMH证据，13例中有6例GIC异常。未发现TCMH的存在与正常/异常GIC之间有任何相关性。远处转移的缺失与TCMH证据之间有正相关趋势。如果同时考虑TCMH和GIC，则远处转移的存在、缺乏TCMH和/或异常GIC之间存在显著相关性。得出的结论是，肾癌和播散性疾病患者中通常发现的TCMH缺陷不能仅用GIC缺陷来解释。
