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New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure.

作者信息

Osada H, Uramoto M, Uzawa J, Kajikawa K, Isono K

机构信息

RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan.

出版信息

Agric Biol Chem. 1990 Nov;54(11):2883-7.

PMID:1368648
Abstract

Antibacteriophage antibiotics, RK-1441A and B, related to neothramycin were isolated from the culture broth of Streptomyces sp. and their structures were deduced from spectroscopic analyses. The structure of RK-1441A was 8,11-dihydroxy-3,7-dimethoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine. RK-1441B is a tautomeric mixture at C-3 of the structure, 3,8,11-trihydroxy-7-methoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine.

摘要

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