链霉菌属产生的新型24元大环内酯类化合物SPA - 6952A和B

New 24-membered macrolides SPA-6952A and B produced by Streptomyces sp.

作者信息

Hosotani Nobuo, Kumagai Kazuo, Nakagawa Hiroyuki, Shimatani Takuro, Saji Ikutaro

机构信息

Exploratory Research Group, Research Division, Sumitomo Pharmaceuticals Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan.

出版信息

J Antibiot (Tokyo). 2005 Jun;58(6):409-11. doi: 10.1038/ja.2005.52.

DOI:10.1038/ja.2005.52

PMID:16156518

Abstract

Two new 24-membered macrolides, SPA-6952A and B, were isolated from the fermentation broth of Streptomyces sp. SPA-6952. The structures of the new macrolides were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells.

摘要

从链霉菌属菌株SPA-6952的发酵液中分离出两种新的24元大环内酯类化合物，SPA-6952A和B。通过光谱分析，包括二维核磁共振技术确定了这些新大环内酯类化合物的结构。这些化合物对人早幼粒细胞白血病HL-60细胞表现出细胞毒性活性。