BARBEAU A, MURPHY G F, SOURKES T L
Science. 1961 May 26;133(3465):1706-7. doi: 10.1126/science.133.3465.1706-a.
The urinary excretion of catecholamines has been measured in 32 patients with disorders of the basal ganglia. Sixteen patients with Parkinsonism (idiopathic, postencephalitic, and arteriosclerotic types) had a significantly lower amount of dopamine in the urine during a 24-hour period than a group of 24 normal control subjects. In a group of 16 patients with various striatal syndromes the excretion of dopamine and epinephrine was significantly higher than normal. Norepinephrine excretion was similar in the three groups. The lowest mean value of urinary dopamine was found in postencephalitic Parkinsonism; the highest occurred in Wilson's disease.
对32例基底神经节疾病患者的儿茶酚胺尿排泄量进行了测定。16例帕金森病患者（特发性、脑炎后和动脉硬化型）在24小时内尿中的多巴胺含量明显低于24名正常对照者。在一组16例患有各种纹状体综合征的患者中，多巴胺和肾上腺素的排泄量明显高于正常水平。三组中去甲肾上腺素的排泄量相似。脑炎后帕金森病患者尿多巴胺的平均含量最低；而肝豆状核变性患者尿多巴胺的平均含量最高。
