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用放线菌素D处理对突变频率的改变。

Alteration of mutation frequency by treatment with actinomycin D.

作者信息

BURDETTE W J

出版信息

Science. 1961 Jan 6;133(3445):40. doi: 10.1126/science.133.3445.40.

DOI:10.1126/science.133.3445.40
PMID:13688945
Abstract

The frequency of lethal mutations occurring in Drosophila melanogaster was reduced by approximately one-half when irradiated males were treated with actinomycin D, which also inhibited the appearance of melanotic atypical growths in the strain used for the study.

摘要

当用放线菌素D处理受辐射的雄性果蝇时，黑腹果蝇中发生的致死突变频率降低了约一半，放线菌素D也抑制了用于该研究的品系中黑色素瘤非典型生长的出现。

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Studies on the combined effect of actinomycin D and x-radiation.放线菌素D与X射线联合效应的研究。
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引用本文的文献

1
Mutations in rDNA. 2. Effects of Actinomycin D on chromatid aberration induction in nucleolus organizer regions.rDNA 突变。2. 放线菌素 D 对核仁组织者区域染色单体畸变诱导的影响。
Theor Appl Genet. 1982 Jun;63(2):161-7. doi: 10.1007/BF00303701.
2
THE EFFECTS OF CHLORAMPHENICOL, STREPTOMYCIN AND PENICILLIN ON THE INDUCTION OF MUTATIONS BY X-RAYS IN DROSOPHILA MELANOGASTER.氯霉素、链霉素和青霉素对X射线诱导黑腹果蝇突变的影响。
Z Vererbungsl. 1963 Aug 13;94:121-5. doi: 10.1007/BF00895889.
3
Inhibition of mouse skin tumorigenesis by actinomycin D.
放线菌素D对小鼠皮肤肿瘤发生的抑制作用。
Proc Natl Acad Sci U S A. 1965 Jun;53(6):1353-60. doi: 10.1073/pnas.53.6.1353.
4
Actinomycin D-induced phenocopies in Drosophila melanogaster and their relevance to the time of gene action.放线菌素D诱导的黑腹果蝇拟表型及其与基因作用时间的相关性。
Genetica. 1972;43(2):207-22. doi: 10.1007/BF00123627.
5
Mutagenic effects of some anticancer antibiotics.某些抗癌抗生素的诱变作用。
Cancer Chemother Pharmacol. 1979;3(3):143-60. doi: 10.1007/BF00262415.