Cutaneous reactions to practolol. Clinical and histopathological study.

In twelve patients with cutaneous reactions to practolol the clinical appearance of the rash was variable, including eczematous, exanthematous, lichenoid, and psoriasiform eruptions, and one exfoliative dermatitis. The development of the rash and its reappearance after oral challenge were slow. But histological findings were almost identical and were not those of any other drug eruption. Vacuolated and dyskeratotic epidermal cells and mild disorganization with extra mitoses of the epidermal cells were seen.