Carter B J
Targeted Genetics Corporation, Seattle, Washington.
Curr Opin Biotechnol. 1992 Oct;3(5):533-9. doi: 10.1016/0958-1669(92)90082-t.
Adeno-associated virus is a human parvovirus that integrates its DNA genome into host cell chromosomes with very high efficiency. This suggests that adeno-associated virus may be a useful vector for human gene therapy. Interest in adeno-associated virus vectors increased greatly in the last year following reports that adeno-associated virus genome integration may be site specific and occur at preferred sites in the human genome. Several genes relevant to the treatment of genetic or infectious diseases have been expressed in adeno-associated virus vectors in vitro.
腺相关病毒是一种人类细小病毒，它能以非常高的效率将其DNA基因组整合到宿主细胞染色体中。这表明腺相关病毒可能是一种用于人类基因治疗的有用载体。去年，有报道称腺相关病毒基因组整合可能具有位点特异性，且发生在人类基因组中的优先位点，此后人们对腺相关病毒载体的兴趣大幅增加。与遗传或传染病治疗相关的几个基因已在体外的腺相关病毒载体中得到表达。
