Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
J Virol. 2014 Feb;88(3):1404-20. doi: 10.1128/JVI.02046-13. Epub 2013 Nov 20.
Viruses employ a variety of strategies to usurp and control cellular activities through the orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear compartments. Formation of such specialized virus-induced cellular microenvironments, which have been termed viroplasms, virus factories, or virus replication centers, complexes, or compartments, depends on molecular interactions between viral and cellular factors that participate in viral genome expression and replication and are in some cases associated with sites of virion assembly. These virus-induced compartments function not only to recruit and concentrate factors required for essential steps of the viral replication cycle but also to control the cellular mechanisms of antiviral defense. In this review, we summarize characteristic features of viral replication compartments from different virus families and discuss similarities in the viral and cellular activities that are associated with their assembly and the functions they facilitate for viral replication.
病毒采用多种策略，通过将大分子有组织地募集到特定的细胞质或核区室，从而篡夺和控制细胞活动。形成这种专门的病毒诱导的细胞微环境，被称为类病毒体、病毒工厂或病毒复制中心、复合物或区室，取决于参与病毒基因组表达和复制的病毒和细胞因子之间的分子相互作用，在某些情况下，还与病毒体组装的部位相关。这些病毒诱导的区室不仅用于募集和浓缩病毒复制周期必需步骤所需的因子，而且还用于控制抗病毒防御的细胞机制。在这篇综述中，我们总结了不同病毒科的病毒复制区室的特征，并讨论了与它们的组装以及它们为病毒复制提供便利的功能相关的病毒和细胞活动的相似性。
