Yu V C, Näär A M, Rosenfeld M G
Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093-0648.
Curr Opin Biotechnol. 1992 Dec;3(6):597-602. doi: 10.1016/0958-1669(92)90002-z.
In the past year, additional experimental data have expanded our understanding of the molecular mechanisms that underlie nuclear receptor control of regulatory programs. It is increasingly clear that steroid members (e.g. glucocorticoid and estrogen) and non-steroid members (e.g. retinoic acid, thyroid hormone, and vitamin D) of the nuclear receptor superfamily may utilize distinct strategies in achieving their complex control of gene regulation.
在过去的一年里，更多的实验数据拓展了我们对核受体调控程序分子机制的理解。越来越明显的是，核受体超家族的类固醇成员（如糖皮质激素和雌激素）和非类固醇成员（如视黄酸、甲状腺激素和维生素D）在实现其对基因调控的复杂控制时可能采用不同的策略。
