Karahanyan E, Milousheva J, Dimitrov C, Marshavelova Y
Department of Pediatrics, University of Medicine, Plovdiv, Bulgaria.
Folia Med (Plovdiv). 1992;34(3-4):22-8.
Twenty four patients (14 girls and 10 boys aged six months to 23 years) with congenital hypothyroidism were studied. The diagnoses of all subjects were made 15 days to one year after birth. After being diagnosed, each child was started immediately on replacement hormonotherapy. Parameters of their physical and mental development were analyzed depending on the type of thyroid disorder, patient age at the beginning of treatment and the adequacy of treatment. These parameters were within the normal limits for 71 percent of the patients. However, the remaining 29 percent of the patients were mentally retarded. The authors' assumption is that the lower intellectual parameters for these patients were primarily a result of delayed diagnoses and irregularly conducted treatments in household surroundings.
对24例先天性甲状腺功能减退症患者（14名女孩和10名男孩，年龄6个月至23岁）进行了研究。所有受试者均在出生后15天至1年确诊。确诊后，每个孩子立即开始接受替代激素治疗。根据甲状腺疾病类型、治疗开始时的患者年龄和治疗的充分性，分析了他们的身心发育参数。这些参数在71%的患者中处于正常范围。然而，其余29%的患者存在智力发育迟缓。作者推测，这些患者较低的智力参数主要是由于家庭环境中诊断延迟和治疗不规范所致。
