Bodin P, Travo P
Centre de Recherche de Biochimie Macromoléculaire du CNRS, Montpellier, France.
J Cardiovasc Pharmacol. 1990;16 Suppl 3:S25-8.
We investigated the effects of 2-(diethylamino)-ethyl-tetrahydro-alpha-(l-naphthylmethyl)-2-furanpro pionate (naftidrofuryl) on both the contraction and the proliferation of cultured rat aortic myocytes elicited by serotonin. Cells were cultured under controlled conditions, both on microcarrier beads and in microwells. The results show that naftidrofuryl alone had no effect on the properties of vascular smooth muscle cells. However, in the presence of serotonin, naftidrofuryl inhibits the contraction and the proliferation of smooth muscle cells.
我们研究了2-(二乙氨基)-乙基-四氢-α-(1-萘甲基)-2-呋喃丙酸酯（萘呋胺酯）对血清素诱导的培养大鼠主动脉肌细胞收缩和增殖的影响。细胞在可控条件下，在微载体珠和微孔板上进行培养。结果表明，单独使用萘呋胺酯对血管平滑肌细胞的特性没有影响。然而，在血清素存在的情况下，萘呋胺酯可抑制平滑肌细胞的收缩和增殖。
