Van Heyningen V, Hastie N D
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
Trends Genet. 1992 Jan;8(1):16-21. doi: 10.1016/0168-9525(92)90019-z.
Wilms' tumour, a paediatric malignancy of the kidney, is a striking example of the relationship between aberrant development and cancer. Several different genetic loci have been implicated in the aetiology of the tumour; genomic imprinting also plays a role. One Wilms' tumour predisposition gene (WT1), encoding a zinc finger protein, is expressed in a limited set of tissues, including developing nephrons and gonads. The biology and genetics of Wilms' tumour underline the developmental relationship between kidneys and gonads.
肾母细胞瘤是一种小儿肾脏恶性肿瘤，是发育异常与癌症之间关系的一个显著例子。几个不同的基因位点与该肿瘤的病因有关；基因组印记也起作用。一种肾母细胞瘤易感基因（WT1）编码一种锌指蛋白，在包括发育中的肾单位和性腺在内的一组有限组织中表达。肾母细胞瘤的生物学和遗传学强调了肾脏与性腺之间的发育关系。
