Pinto A, Hwang W S, Wong A L, Seagram C G
Department of Pathology, Alberta Children's Hospital, Calgary, Canada.
Mod Pathol. 1992 Nov;5(6):639-42.
Two cases of giant cell fibroblastoma in children are presented. Histologic features included a dense fibrous tissue stroma with multinucleated giant cells lining sinusoid-like spaces. Immunohistochemical stains and electron microscopy provide evidence of a fibroblastic origin of the tumor cells. Ultrastructure of the multinucleated cells revealed segmentation of the nuclei with multiple centrioles, suggesting that an abnormality in the division of the tumor cells may be the mechanism for the formation of the giant cells.
本文报告了两例儿童巨细胞纤维母细胞瘤。组织学特征包括致密的纤维组织基质，其中多核巨细胞排列在窦状样间隙内衬。免疫组织化学染色和电子显微镜检查提供了肿瘤细胞成纤维细胞起源的证据。多核细胞的超微结构显示细胞核有分割且有多个中心粒，提示肿瘤细胞分裂异常可能是巨细胞形成的机制。
