May W E, Benner B A, Wise S A, Schuetzle D, Lewtas J
National Institute of Standards and Technology, Gaithersburg, MD 20899.
Mutat Res. 1992 Jan-Mar;276(1-2):11-22. doi: 10.1016/0165-1110(92)90052-b.
Standard Reference Materials (SRMs) from the National Institute of Standards and Technology (NIST) are often used in methods development and interlaboratory comparison studies since they are homogeneous and readily available to the scientific community. SRM 1649 (urban dust/organics), SRM 1650 (diesel particulate matter), and SRM 1597 (complex mixture of polycyclic aromatic hydrocarbons from coal tar) are three environmental samples which have been used by the scientific community for these purposes. These SRMs were originally developed to assist laboratories in validating analytical procedures for the determination of polycyclic organic compounds in complex mixtures. In addition, these SRMs have been valuable for the comparison of methodologies for bacterial bioassays and the development of bioassay-directed fractionation and bioassay-directed chemical analysis techniques. Most recently these SRMs were chosen for use as test samples in a collaborative study coordinated by the World Health Organization--International Programme on Chemical Safety. This paper provides a summary of much of the work to date (published and unpublished) on the chemical and biological characterization of these three SRMs. Information regarding the availability of other NIST SRMs that might be useful for these types of studies are provided also.
美国国家标准与技术研究院（NIST）的标准参考物质（SRM）常用于方法开发和实验室间比对研究，因为它们性质均一，科学界易于获取。SRM 1649（城市灰尘/有机物）、SRM 1650（柴油颗粒物）和SRM 1597（煤焦油中多环芳烃的复杂混合物）是科学界用于这些目的的三种环境样品。这些SRM最初是为帮助实验室验证复杂混合物中多环有机化合物测定的分析程序而开发的。此外，这些SRM对于细菌生物测定方法的比较以及生物测定导向的分级分离和生物测定导向的化学分析技术的开发也很有价值。最近，这些SRM被选作世界卫生组织——国际化学品安全规划署协调的一项合作研究中的测试样品。本文总结了迄今为止关于这三种SRM化学和生物学特性的许多工作（已发表和未发表的）。还提供了有关其他可能对这类研究有用的NIST SRM的可得信息。
