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3-甲基胆蒽和苯巴比妥对氨基酸掺入蛋白质的影响。

Effects of 3-methylcholanthrene and phenobarbital on amino acid incorporation into protein.

作者信息

GELBOIN H V, SOKOLOFF L

出版信息

Science. 1961 Sep 1;134(3479):611-2. doi: 10.1126/science.134.3479.611.

DOI:10.1126/science.134.3479.611
PMID:13704253
Abstract

Treatment of rats with methylcholanthrene and phenobarbital, two compounds known to enhance microsomal enzyme activity, stimulates the incorporation of free or soluble ribonucleic acid bound amino acid into proteins of cell-free liver preparations. Mitochondria, microsomes, and cell sap all contribute to the methylcholanthrene effect on the incorporation of free amino acid.

摘要

用已知能增强微粒体酶活性的两种化合物——甲基胆蒽和苯巴比妥处理大鼠，可刺激游离或可溶性核糖核酸结合氨基酸掺入无细胞肝制剂的蛋白质中。线粒体、微粒体和细胞液都对甲基胆蒽影响游离氨基酸的掺入有作用。

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1
Effects of 3-methylcholanthrene and phenobarbital on amino acid incorporation into protein.3-甲基胆蒽和苯巴比妥对氨基酸掺入蛋白质的影响。
Science. 1961 Sep 1;134(3479):611-2. doi: 10.1126/science.134.3479.611.
2
Studies on the incorporation of delta-aminolevulinic acid into microsomal hemoprotein: effect of 3-methylcholanthrene and phenobarbital.
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Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. I. Resolution, purificaton, and molecular properties.从经苯巴比妥和3-甲基胆蒽预处理的兔肝脏微粒体中纯化得到的多种细胞色素P-450形式。I. 分离、纯化及分子特性
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引用本文的文献

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Studies on azo-dye carcinogenesis in rat liver. The effect of 4-dimethylamino-3'-methylazobenzene on the incorporation of [C]leucine into rat-liver microsomal protein.大鼠肝脏偶氮染料致癌作用的研究。4-二甲基氨基-3'-甲基偶氮苯对[C]亮氨酸掺入大鼠肝脏微粒体蛋白的影响。
Biochem J. 1963 Jul;88(1):106-14. doi: 10.1042/bj0880106.
2
METHYLCHOLANTHRENE-INDUCED CHANGES IN RAT LIVER NUCLEAR RNA.甲基胆蒽诱导的大鼠肝脏核RNA变化
Proc Natl Acad Sci U S A. 1964 Nov;52(5):1219-26. doi: 10.1073/pnas.52.5.1219.
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[Enzyme induction and increase of endoplasmic reticulum in liver cells during phenobarbital (Luminal) therapy].
[苯巴比妥（鲁米那）治疗期间肝细胞中的酶诱导作用及内质网增加]
Klin Wochenschr. 1963 Mar 15;41:276-82. doi: 10.1007/BF01483392.
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Int Arch Arbeitsmed. 1970;26(1):31-44.
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Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study.苯巴比妥诱导微粒体药物代谢酶系统的合成及其与内质网膜增殖的关系。一项形态学和生物化学研究。
J Cell Biol. 1965 Jun;25(3):627-39. doi: 10.1083/jcb.25.3.627.
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[On 2-benzolsulfonylamino-5(beta-methoxy-ethoxy)-pyrimidine (glycodiazine. V. In vitro and in vivo experiments on the action of phenylethylbarbituric acid (Luminal) on the metabolism and blood sugar reducing effect of glycodiazine].[关于2-苯磺酰氨基-5（β-甲氧基-乙氧基）-嘧啶（糖二氮嗪。V. 苯巴比妥（鲁米那）对糖二氮嗪代谢及降血糖作用的体外和体内实验]
Naunyn Schmiedebergs Arch Pharmakol Exp Pathol. 1966;255(2):200-20.
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Effect of some polycyclic aromatic hydrocarbons on protein synthesis in vitro.某些多环芳烃对体外蛋白质合成的影响。
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