St Clair E W, Angellilo J C, Singer K H
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Arthritis Rheum. 1992 Jan;35(1):62-6. doi: 10.1002/art.1780350110.
The potential role of cell adhesion molecules in the pathogenesis of Sjögren's syndrome (SS) was assessed by examining their expression in salivary gland (SGL) tissue.
Intercellular adhesion molecule type 1 (ICAM-1), lymphocyte function-associated antigen type 1 (LFA-1), LFA-3, CD2, and CD44 expression were determined using indirect immunofluorescence techniques.
In inflamed labial SGL tissue, ICAM-1 expression was evident on infiltrating LFA-1+/CD2+/LFA-3+ mononuclear cells, and to a limited extent on SGL acinar epithelial cells adjacent to sites of intense inflammation.
In SS, the SGL microenvironment is characterized by only a modest up-regulation of ICAM-1 expression on epithelial cells, despite the presence of T cells bearing an activated phenotype.
通过检测细胞黏附分子在唾液腺（SGL）组织中的表达，评估其在干燥综合征（SS）发病机制中的潜在作用。
采用间接免疫荧光技术测定细胞间黏附分子-1（ICAM-1）、淋巴细胞功能相关抗原-1（LFA-1）、LFA-3、CD2和CD44的表达。
在炎症性唇腺SGL组织中，ICAM-1在浸润的LFA-1+/CD2+/LFA-3+单核细胞上表达明显，在紧邻严重炎症部位的SGL腺泡上皮细胞上有有限表达。
在SS中，尽管存在具有活化表型的T细胞，但SGL微环境的特征是上皮细胞上ICAM-1表达仅适度上调。
