Grimm G, Madl C, Katzenschlager R, Oder W, Ferenci P, Gangl A
Department of Neurology, University of Vienna, Austria.
Electroencephalogr Clin Neurophysiol. 1992 Feb;82(2):119-24. doi: 10.1016/0013-4694(92)90154-a.
Detailed evoked potentials (EPs) were studied in 52 patients (28.7 +/- 11.9 years) with Wilson's disease (WD). Various peak latencies, interpeak latencies and amplitudes of somatosensory, auditory brain-stem and visual EPs were significantly abnormal in the group of 28 neurologically symptomatic patients as compared to controls. Interhemisphere latency and amplitude differences tended to be increased without reaching significance, indicating a symmetrical rather than focal subclinical brain involvement. Selected conduction times of at least 1 EP modality were prolonged in all 4 patients with severe, in 16 of 18 with moderate, in 4 of 6 with mild, and in 4 of 24 patients without neurological symptoms. Auditory brain-stem and somatosensory EPs were more frequently prolonged than visual EPs (more abnormalities with check sizes of 13 than 54 min of arc). Cortical somatosensory EPs correlated well (P much less than 0.01) with either Fz or earlobe reference.
对52例（年龄28.7±11.9岁）威尔逊病（WD）患者进行了详细的诱发电位（EP）研究。与对照组相比，28例有神经症状的患者的体感、听觉脑干和视觉EP的各种峰潜伏期、峰间潜伏期和波幅均显著异常。半球间潜伏期和波幅差异有增加趋势，但未达到显著水平，表明存在对称性而非局灶性亚临床脑受累。在4例重症患者、18例中度患者中的16例、6例轻度患者中的4例以及24例无神经症状的患者中的4例中，至少1种EP模式的选定传导时间延长。听觉脑干和体感EP比视觉EP更常延长（13°视标时比54°视标时有更多异常）。皮层体感EP与Fz或耳垂参考点相关性良好（P远小于0.01）。
