Grimm G, Prayer L, Oder W, Ferenci P, Madl C, Knoflach P, Schneider B, Imhof H, Gangl A
1st Department of Medicine, University of Vienna, Austria.
Neurology. 1991 Feb;41(2 ( Pt 1)):272-6. doi: 10.1212/wnl.41.2_part_1.272.
We assessed the functional and structural brain disturbances in Wilson's disease (WD) by evoked potentials (EPs) and magnetic resonance imaging (MRI). All the 25 neurologically symptomatic and 44% of the 16 asymptomatic patients, assessed by both EPs (n = 48) and imaging (n = 41), had at least 1 abnormality of either prolonged EP conduction times, imaging-outlined presence of cerebral lesions, or brain atrophy. Our findings indicate that EPs and MRI are sensitive techniques for the evaluation of brain involvement in WD.
我们通过诱发电位（EPs）和磁共振成像（MRI）评估了肝豆状核变性（WD）患者大脑的功能和结构紊乱情况。在通过EPs（n = 48）和成像检查（n = 41）评估的25例有神经症状的患者以及16例无症状患者中的44%中发现，至少存在以下一种异常情况：诱发电位传导时间延长、成像显示存在脑损伤或脑萎缩。我们的研究结果表明，诱发电位和磁共振成像都是评估肝豆状核变性患者脑部受累情况的敏感技术。
