Kühlkamp V, Haasis R, Seipel L
Medizinische Klinik Abteilung III, Eberhard-Karls-Universität, Tübingen, Federal Republic of Germany.
Pacing Clin Electrophysiol. 1992 Jan;15(1):71-80. doi: 10.1111/j.1540-8159.1992.tb02903.x.
For elucidation of atrial electrophysiology and vulnerability an electrophysiological study was performed in 45 patients with documented paroxysmal atrial fibrillation and a control group (n = 46). Atrial vulnerability was assessed by programmed atrial stimulation with up to two extrastimuli during sinus rhythm and paced cycle lengths of 600 msec, 430 msec and 330 msec. Sustained atrial fibrillation or flutter was induced in 37/45 patients with paroxysmal atrial fibrillation in contrast to 9/46 patients in the control group (P less than 0.001). Left atrial diameter (M-mode echocardiogram), P wave duration, sinus cycle length, sinus node recovery time, and the effective refractory period of the right atrium were not significantly different between the two study groups. Intraatrial conduction time from the high right atrium (HRA) to the basal right atrium (A) and the functional refractory period of the right atrium were significantly longer in patients with paroxysmal atrial fibrillation.
为阐明心房电生理学及易损性，对45例记录有阵发性心房颤动的患者及一个对照组（n = 46）进行了电生理研究。在窦性心律及600毫秒、430毫秒和330毫秒的起搏周期长度下，通过程控心房刺激并施加最多两个额外刺激来评估心房易损性。37/45例阵发性心房颤动患者诱发出持续性心房颤动或心房扑动，而对照组为9/46例患者（P小于0.001）。两组研究对象的左心房直径（M型超声心动图）、P波时限、窦性周期长度、窦房结恢复时间及右心房有效不应期无显著差异。阵发性心房颤动患者从高位右心房（HRA）至右心房基底部（A）的心房内传导时间及右心房功能不应期显著延长。
