Kühlkamp V, Meerhof J, Schmidt F, Mayer F, Ickrath O, Haasis R, Seipel L
Medizinische Klinik Abteilung III, Eberhard-Karls-Universität, Tübingen, West Germany.
Am J Cardiol. 1990 Mar 1;65(9):628-32. doi: 10.1016/0002-9149(90)91042-5.
The effects of intravenous cibenzoline (1.5 mg/kg) on atrial vulnerability and electrophysiology were assessed in 25 patients with documented paroxysmal atrial fibrillation (AF), in whom sustained (greater than 30 seconds) AF was induced by atrial stimulation with up to 2 extrastimuli and paced rates between 100 and 180 beats/min. In 7 patients AF persisted despite the application of cibenzoline, and in 8 patients the induction of sustained AF was prevented by cibenzoline. Intraatrial conduction time, flutter cycle length and shortest ventricular cycle length during AF were increased by cibenzoline (p less than or equal to 0.01). Sinus cycle length was decreased (p less than or equal to 0.05), whereas sinus node recovery time remained unchanged. The effective refractory period of the right atrium was not significantly affected. Eight patients with frequent episodes of paroxysmal AF received oral cibenzoline for control of paroxysmal AF irrespective of the efficacy of intravenous cibenzoline. Prevention of stimulation-induced AF predicted successful treatment of paroxysmal AF (p = 0.018). Cibenzoline could be effective in the treatment of atrial arrhythmias, and selection of an antiarrhythmic therapy for recurrent AF seems to be useful.
在25例记录有阵发性心房颤动（AF）的患者中，评估了静脉注射西苯唑啉（1.5mg/kg）对心房易损性和电生理的影响。这些患者通过心房刺激（最多2次额外刺激）和100至180次/分钟的起搏频率诱发持续（超过30秒）房颤。7例患者应用西苯唑啉后房颤仍持续，8例患者西苯唑啉预防了持续房颤的诱发。西苯唑啉使房颤期间的心房内传导时间、扑动周期长度和最短心室周期长度增加（p≤0.01）。窦性周期长度缩短（p≤0.05），而窦房结恢复时间保持不变。右心房的有效不应期未受到显著影响。8例阵发性房颤频繁发作的患者接受口服西苯唑啉以控制阵发性房颤，而不考虑静脉注射西苯唑啉的疗效。预防刺激诱发的房颤预示着阵发性房颤治疗成功（p = 0.018）。西苯唑啉可能对阵发性心律失常有效，为复发性房颤选择抗心律失常治疗似乎是有用的。
