Mildvan D, Machado S G, Wilets I, Grossberg S E
Division of Infectious Diseases, Beth Israel Medical Center, New York, New York 10003.
Lancet. 1992 Feb 22;339(8791):453-6. doi: 10.1016/0140-6736(92)91058-g.
To improve evaluation of new antiretroviral drugs in the acquired immunodeficiency syndrome (AIDS), sensitive biological markers that accurately predict response to treatment are needed. Two possible markers are endogenous interferon (E-IFN), which is a cytokine involved in the pathophysiology of AIDS, and serum triglycerides (TG), which are raised in patients with AIDS, possibly reflecting enhanced cytokine activity. E-IFN, TG, body-mass index, CD4 count, and HIV p24 were measured in 19 patients (15 with AIDS, 4 with AIDS-related complex), who were part of the phase II licensing trial of zidovudine (ZDV). 10 received ZDV and 9 received placebo. Rapid, significant, and sustained declines from initial values in E-IFN and TG concentrations were observed in ZDV patients but not in placebo patients. Baseline values of E-IFN and TG concentrations after 4 months on ZDV treatment were both important contributors to long-term survival. The findings suggest that these indicators of abnormal cytokine expression may be useful measures of not only disease severity but also efficacy of antiretroviral therapy in AIDS.
为了改进对获得性免疫缺陷综合征（艾滋病）中新抗逆转录病毒药物的评估，需要能够准确预测治疗反应的敏感生物学标志物。两种可能的标志物是内源性干扰素（E-IFN），它是一种参与艾滋病病理生理学的细胞因子，以及血清甘油三酯（TG），艾滋病患者的血清甘油三酯会升高，这可能反映了细胞因子活性增强。在19名患者（15名艾滋病患者，4名艾滋病相关综合征患者）中测量了E-IFN、TG、体重指数、CD4计数和HIV p24，这些患者参与了齐多夫定（ZDV）的II期许可试验。10名患者接受ZDV治疗，9名患者接受安慰剂治疗。在接受ZDV治疗的患者中观察到E-IFN和TG浓度从初始值迅速、显著且持续下降，而在接受安慰剂治疗的患者中未观察到这种情况。接受ZDV治疗4个月后的E-IFN和TG浓度基线值都是长期生存的重要因素。这些发现表明，这些细胞因子表达异常的指标不仅可能是疾病严重程度的有用衡量指标，也是艾滋病抗逆转录病毒治疗疗效的有用衡量指标。
