Kraaier V, Van Huffelen A C, Wieneke G H, Van der Worp H B, Bär P R
Department of Clinical Neurophysiology, University Hospital Utrecht, The Netherlands.
Electroencephalogr Clin Neurophysiol. 1992 Mar;82(3):208-12. doi: 10.1016/0013-4694(92)90169-i.
Hyperventilation leads to an increase in slow EEG activity as well as to a decrease in alpha activity. These effects may be considered a result of reduction in cerebral blood flow due to vasoconstriction, but metabolic factors, such as alkalosis and the increased formation of cerebral lactate, may also have to be taken into account. As indomethacin decreases cerebral blood flow it is possible to study cerebral vasoconstriction, without concomitant metabolic alkalosis or cerebral lactate formation. Two parallel groups of 12 healthy male subjects (age 20-25) were studied with quantitative EEG (qEEG) and cerebral blood flow velocity as parameters. In the first group the effect of 100 mg indomethacin was studied. In the parallel group a standardized hyperventilation procedure was performed. In the indomethacin group the blood flow velocity decreased to 60% of the initial value; the qEEG showed a 0.5 Hz slowing of the alpha peak frequency (P less than 0.01) and a decrease in the power of the alpha band without any change in the delta or theta band. In the hyperventilation group the blood flow velocity decreased to 63% of the initial value and the qEEG showed a marked increase in delta and theta activity (P less than 0.01), but a non-significant change in alpha peak frequency. Indomethacin and hyperventilation caused similar degrees of vasoconstriction; however, the increase in qEEG slow wave activity, which was observed only in the hyperventilation group, is apparently related to metabolic rather than haemodynamic factors.
过度换气会导致脑电图慢波活动增加以及α波活动减少。这些效应可能被认为是由于血管收缩导致脑血流量减少的结果，但代谢因素，如碱中毒和脑乳酸形成增加，也可能需要考虑在内。由于吲哚美辛会减少脑血流量，因此有可能在不伴有代谢性碱中毒或脑乳酸形成的情况下研究脑血管收缩。以定量脑电图（qEEG）和脑血流速度为参数，对两组各12名健康男性受试者（年龄20 - 25岁）进行了平行研究。第一组研究了100毫克吲哚美辛的作用。在平行组中进行了标准化的过度换气程序。在吲哚美辛组中，血流速度降至初始值的60%；qEEG显示α波峰值频率减慢0.5赫兹（P < 0.01），α波频段功率降低，而δ波或θ波频段无变化。在过度换气组中，血流速度降至初始值的63%，qEEG显示δ波和θ波活动显著增加（P < 0.01），但α波峰值频率无显著变化。吲哚美辛和过度换气引起的血管收缩程度相似；然而，仅在过度换气组中观察到的qEEG慢波活动增加显然与代谢而非血流动力学因素有关。
