Yamatani M, Konishi T, Murakami M, Okuda T
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Pediatr Neurol. 1995 Jul;13(1):42-5. doi: 10.1016/0887-8994(95)00089-x.
In 20 patients with epilepsy, electroencephalography (EEG) slowing was quantitatively characterized during standardized hyperventilation activation (respiratory rate: 30/min, threefold elevation of total expiratory volume, duration: 4 min) and changes in cerebral blood flow and velocity in the right common carotid artery were monitored with the Doppler ultrasonic method. Thirteen age-matched normal children served as controls. The results were as follows: (1) EEG slowing in the epilepsy group was greater compared with controls. (2) There was a significant decrease in mean frequency (decrease in alpha power and increase in delta power) during hyperventilation in the epilepsy group, but no significant change in the controls. (3) The decrease in cerebral blood flow (CBF) was greater in the epilepsy group at the beginning of hyperventilation, possibly related to the greater EEG slowing. (4) The percentage of CBF at the end of hyperventilation was similar in the epilepsy and control groups. The difference in EEG response to hyperventilation between the 2 groups may be due to differences in the decrease in CBF volume and the sensitivity of the change in CBF.
对20例癫痫患者在标准化过度通气激活期间（呼吸频率：30次/分钟，总呼气量增加三倍，持续时间：4分钟）进行脑电图（EEG）减慢的定量分析，并采用多普勒超声法监测右侧颈总动脉的脑血流和血流速度变化。选取13名年龄匹配的正常儿童作为对照。结果如下：（1）癫痫组的EEG减慢程度比对照组更大。（2）癫痫组在过度通气期间平均频率显著降低（α波功率降低，δ波功率增加），而对照组无显著变化。（3）癫痫组在过度通气开始时脑血流量（CBF）下降幅度更大，这可能与EEG减慢程度更大有关。（4）癫痫组和对照组在过度通气结束时的CBF百分比相似。两组对过度通气的EEG反应差异可能是由于CBF体积下降和CBF变化敏感性的差异所致。
