Luthman J, Lindqvist E, Dell'Anna E, Kojima H, Shiotani T, Tachizawa H, Olson L
Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden.
Pharmacol Biochem Behav. 1992 Jan;41(1):231-4. doi: 10.1016/0091-3057(92)90088-w.
Alterations in brain tissue levels of monoamines and monoamine metabolites were studied in gerbils 60 min after cerebral ischemia induced by 10 min carotid ligation after pretreatment with the antiischemic drug DM-9384 (1, 3, 10, 30 mg/kg, PO). The DA levels decreased in striatum after the ischemia, while cortical and hippocampal DA levels increased. The DOPAC levels increased in cortex, but were essentially unaffected in other regions. The HVA levels increased in all forebrain regions studied. NA levels decreased in hippocampus and superior colliculus, while a general increase in MHPG levels was seen. Decreases in 5-HT levels were seen in all forebrain regions except cortex. The 10 mg/kg and 30 mg/kg doses of DM-9384 counteracted the decrease in striatal 5-HT and hypothalamic MHPG/NA ratio, respectively. Thus pretreatment with DM-9384 exerted minor protective effects on the alterations induced in monoamine systems by transient forebrain ischemia.
在用抗缺血药物DM - 9384（1、3、10、30毫克/千克，口服）预处理后，通过10分钟颈动脉结扎诱导沙土鼠脑缺血60分钟后，研究了脑组织中单胺和单胺代谢物水平的变化。缺血后纹状体中的多巴胺（DA）水平降低，而皮质和海马中的DA水平升高。二羟基苯乙酸（DOPAC）水平在皮质中升高，但在其他区域基本未受影响。高香草酸（HVA）水平在所研究的所有前脑区域均升高。去甲肾上腺素（NA）水平在海马和上丘中降低，而3 - 甲氧基 - 4 - 羟基苯乙二醇（MHPG）水平普遍升高。除皮质外，所有前脑区域的5 - 羟色胺（5 - HT）水平均降低。10毫克/千克和30毫克/千克剂量的DM - 9384分别抵消了纹状体中5 - HT的降低和下丘脑中MHPG/NA比值的降低。因此，DM - 9384预处理对短暂性前脑缺血诱导的单胺系统变化具有轻微的保护作用。
