HUGGINS C, OKAMOTO R
J Exp Med. 1960 Nov 1;112(5):883-93. doi: 10.1084/jem.112.5.883.
Integrity of the portal vein is a condition for normal function of the reproductive tract in female rats. Section of the portal vein (PVS) always abolished periodic sexual function. In a series of 23 animals, 6 developed continuous estrus and other signs of the presence of excessive amounts of estrogenic hormones; yet the ovaries of these rats were small. In 6 other rats there was growth of the prostate and additional evidence of increased activity of androgenic hormones. Many rats failed to become pregnant and nearly all pregnant rats aborted. Except for a decrease in lipid content, the composition of the liver of PVS rats resembled that of intact mates in the criteria which were applied. The rapid passage of blood through the liver is necessary to conjugate the excessive amounts of steroids which the rat ovary normally produces and an intact portal vein is an essential unit in the mechanism necessary for their partial inactivation.
门静脉的完整性是雌性大鼠生殖道正常功能的一个条件。门静脉切断术（PVS）总会消除周期性性功能。在一系列23只动物中，6只出现持续发情以及其他雌激素过多的迹象；然而这些大鼠的卵巢较小。在另外6只大鼠中，前列腺生长，并有雄激素活性增加的其他证据。许多大鼠未能怀孕，几乎所有怀孕大鼠都流产了。除了脂质含量降低外，PVS大鼠肝脏的组成在所应用的标准方面与完整配对的大鼠相似。血液快速通过肝脏对于结合大鼠卵巢正常产生的过量类固醇是必要的，而完整的门静脉是其部分失活所需机制中的一个基本单元。
