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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Anaesthesia and Intensive Care, Royal Brompton Hospital, London, U.K.

Clin Sci (Lond). 1992 Mar;82(3):315-20. doi: 10.1042/cs0820315.

During pathological states of iron-overload or oxidant stress, low-molecular-mass iron can become available within extracellular fluids. 2. This iron would be converted to the ferrous state were it not for the protective anti-oxidant protein caeruloplasmin. 3. The ferrous-ion-oxidizing activity of caeruloplasmin rapidly converts ferrous ions back to the less reactive ferric state so that they can bind to available binding sites on transferrin. 4. Cerebrospinal fluids, however, often appear to contain low-molecular-mass iron, high levels of ascorbate and low levels of ferroxidase activity with little or no iron-binding capacity. 5. When iron ions are present in cerebrospinal fluid they are therefore likely to be in the ferrous state. 6. The development and application of an assay to speciate and measure ferrous ions in simple aqueous solution and their redox cycling activity in biological fluids is described.

在铁过载或氧化应激的病理状态下，低分子量铁可在细胞外液中出现。2. 若没有保护性抗氧化蛋白铜蓝蛋白，这种铁会转化为亚铁状态。3. 铜蓝蛋白的亚铁离子氧化活性可迅速将亚铁离子转化回活性较低的铁离子状态，使其能够与转铁蛋白上的可用结合位点结合。4. 然而，脑脊液中似乎常常含有低分子量铁、高水平的抗坏血酸和低水平的亚铁氧化酶活性，且铁结合能力很小或没有。5. 因此，当铁离子存在于脑脊液中时，它们很可能处于亚铁状态。6. 本文描述了一种用于在简单水溶液中鉴别和测量亚铁离子及其在生物流体中的氧化还原循环活性的分析方法的开发和应用。

Department of Anaesthesia and Intensive Care, Royal Brompton Hospital, London, U.K.

Clin Sci (Lond). 1992 Mar;82(3):315-20. doi: 10.1042/cs0820315.

During pathological states of iron-overload or oxidant stress, low-molecular-mass iron can become available within extracellular fluids. 2. This iron would be converted to the ferrous state were it not for the protective anti-oxidant protein caeruloplasmin. 3. The ferrous-ion-oxidizing activity of caeruloplasmin rapidly converts ferrous ions back to the less reactive ferric state so that they can bind to available binding sites on transferrin. 4. Cerebrospinal fluids, however, often appear to contain low-molecular-mass iron, high levels of ascorbate and low levels of ferroxidase activity with little or no iron-binding capacity. 5. When iron ions are present in cerebrospinal fluid they are therefore likely to be in the ferrous state. 6. The development and application of an assay to speciate and measure ferrous ions in simple aqueous solution and their redox cycling activity in biological fluids is described.

在铁过载或氧化应激的病理状态下，低分子量铁可在细胞外液中出现。2. 若没有保护性抗氧化蛋白铜蓝蛋白，这种铁会转化为亚铁状态。3. 铜蓝蛋白的亚铁离子氧化活性可迅速将亚铁离子转化回活性较低的铁离子状态，使其能够与转铁蛋白上的可用结合位点结合。4. 然而，脑脊液中似乎常常含有低分子量铁、高水平的抗坏血酸和低水平的亚铁氧化酶活性，且铁结合能力很小或没有。5. 因此，当铁离子存在于脑脊液中时，它们很可能处于亚铁状态。6. 本文描述了一种用于在简单水溶液中鉴别和测量亚铁离子及其在生物流体中的氧化还原循环活性的分析方法的开发和应用。