Berger H M, Mumby S, Gutteridge J M
Department of Pediatrics, University of Leiden, The Netherlands.
Free Radic Res. 1995 Jun;22(6):555-9. doi: 10.3109/10715769509150327.
Redox active iron chelatable to bleomycin is often present in the plasma of cord blood samples taken from preterm and term babies. The low caeruloplasmin and high ascorbate levels in plasma at birth may allow this iron to exist in the reduced ferrous state. In support of this postulate thirteen cord blood samples showing the presence of low molecular mass iron were able to degrade DNA in the presence of bleomycin and plasma.
可被博来霉素螯合的氧化还原活性铁常常存在于从早产和足月婴儿采集的脐带血样本血浆中。出生时血浆中铜蓝蛋白水平低和抗坏血酸水平高可能使这种铁以还原亚铁状态存在。为支持这一假设，13份显示存在低分子量铁的脐带血样本在博来霉素和血浆存在的情况下能够降解DNA。
