Steinschneider M, Tenke C E, Schroeder C E, Javitt D C, Simpson G V, Arezzo J C, Vaughan H G
Department of Neurology, Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Electroencephalogr Clin Neurophysiol. 1992 Mar-Apr;84(2):196-200. doi: 10.1016/0168-5597(92)90026-8.
Cellular generators of the initial cortical auditory evoked potential (AEP) component were determined by analyzing laminar profiles of click-evoked AEPs, current source density, and multiple unit activity (MUA) in primary auditory cortex of awake monkeys. The initial AEP component is a surface-negative wave, N8, that peaks at 8-9 msec and inverts in polarity below lamina 4. N8 is generated by a lamina 4 current sink and a deeper current source. Simultaneous MUA is present from lower lamina 3 to the subjacent white matter. Findings indicate that thalamocortical afferents are a generator of N8 and support a role for lamina 4 stellate cells. Relationships to the human AEP are discussed.
通过分析清醒猴子初级听觉皮层中点击诱发的听觉诱发电位（AEP）的层状分布、电流源密度和多单位活动（MUA），确定了初始皮层听觉诱发电位成分的细胞发生器。初始AEP成分是一个表面负波，即N8，在8 - 9毫秒达到峰值，并在第4层以下极性反转。N8由第4层电流汇和更深层的电流源产生。从第3层下部到相邻白质存在同步的MUA。研究结果表明，丘脑皮质传入神经是N8的发生器，并支持第4层星状细胞的作用。还讨论了与人类AEP的关系。
