大剂量静脉注射人免疫球蛋白治疗难治性多发性肌炎
High-dose intravenous human immunoglobulin in polymyositis resistant to treatment.
作者信息
Jann S, Beretta S, Moggio M, Adobbati L, Pellegrini G
机构信息
Institute of Neurology, University of Milan, Policlinico Hospital, Italy.
出版信息
J Neurol Neurosurg Psychiatry. 1992 Jan;55(1):60-2. doi: 10.1136/jnnp.55.1.60.
Abstract
Two patients were treated with treatment-resistant polymyositis with intravenous immunoglobulin over four days at a dose of 0.4 g/kg/day. Clinical recovery followed within two months. Serum creatine kinase (CK) activity decreased to normal, and a clear improvement in muscle strength was observed. One patient showed neither clinical relapses nor increase in serum CK activity after 20 months. The other showed a mild increase in serum CK activity after 24 months and was successfully retreated with intravenous immunoglobulin. There were no significant adverse side effects.
摘要
两名患有难治性多发性肌炎的患者接受了静脉注射免疫球蛋白治疗，为期四天，剂量为0.4 g/kg/天。两个月内临床症状恢复。血清肌酸激酶（CK）活性降至正常，肌肉力量有明显改善。一名患者在20个月后既无临床复发，血清CK活性也未升高。另一名患者在24个月后血清CK活性轻度升高，再次静脉注射免疫球蛋白治疗成功。未出现明显的不良副作用。
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