EDGAR R S, EPSTEIN R H
Science. 1961 Aug 4;134(3475):327-8. doi: 10.1126/science.134.3475.327.
Mutants of phage T4D can be isolated which multiply in the presence of concentrations of acriflavine inhibitory to the growth of wild-type phage. Bacteria mixedly infected with resistant and sensitive phage are unproductive in the presence of acriflavine. Irradiation of the sensitive phage with ultraviolet light results in inactivation of the function of the gene for acriflavine sensitivity, permitting the mixedly infected complexes to yield phage. This function is inactivated in an exponential manner and has a cross section comparable to cross sections of other gene functions in T4D.
可以分离出噬菌体T4D的突变体，它们能在对野生型噬菌体生长有抑制作用的吖啶黄素浓度下繁殖。在吖啶黄素存在的情况下，被抗性噬菌体和敏感噬菌体混合感染的细菌是无生产性的。用紫外线照射敏感噬菌体导致吖啶黄素敏感性基因的功能失活，从而使混合感染的复合物产生噬菌体。该功能以指数方式失活，其截面与T4D中其他基因功能的截面相当。
