Sinha R P
Antimicrob Agents Chemother. 1977 Sep;12(3):383-9. doi: 10.1128/AAC.12.3.383.
Selection for resistance to acriflavine in Streptococcus cremoris resulted in cross-resistance to the drugs neomycin, streptomycin, ethidium bromide, mitomycin C, and proflavine. Furthermore, the mutants showed resistance to lytic bacteriophages to which the parental strain was sensitive, and, unlike the parent, the mutants grew well at higher temperatures (40 degrees C). Revertants selected independently either for temperature sensitivity or for acriflavine sensitivity lost resistance to all the drugs and dyes but retained the bacteriophage resistance phenotype. The acriflavine-resistant mutation resulted in an increase in resistance by the bacterial cells to sodium dodecyl sulfate, a potent solvent of lipopolysaccharide and lipoprotein. It is suggested that the acriflavine resistance mutation determines the synthesis of a membrane substance resistant to higher temperatures.
对乳脂链球菌中对吖啶黄的抗性进行选择，导致对新霉素、链霉素、溴化乙锭、丝裂霉素C和原黄素产生交叉抗性。此外，突变体对亲本菌株敏感的裂解性噬菌体表现出抗性，并且与亲本不同，突变体在较高温度（40摄氏度）下生长良好。独立选择的对温度敏感或对吖啶黄敏感的回复突变体失去了对所有药物和染料的抗性，但保留了噬菌体抗性表型。吖啶黄抗性突变导致细菌细胞对十二烷基硫酸钠（一种有效的脂多糖和脂蛋白溶剂）的抗性增加。有人提出，吖啶黄抗性突变决定了一种对较高温度有抗性的膜物质的合成。
