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DSP-4 耗竭去甲肾上腺素后对体内黑质纹状体和中脑边缘多巴胺释放的抑制作用：一项微透析研究。

Suppression of nigrostriatal and mesolimbic dopamine release in vivo following noradrenaline depletion by DSP-4: a microdialysis study.

作者信息

Lategan A J, Marien M R, Colpaert F C

机构信息

Neurobiology Division, FONDAX-Groupe de Recherche SERVIER, Puteaux, France.

出版信息

Life Sci. 1992;50(14):995-9. doi: 10.1016/0024-3205(92)90093-5.

DOI:10.1016/0024-3205(92)90093-5
PMID:1372673
Abstract

Pretreatment of rats with the noradrenergic neurotoxin DSP-4 selectively reduced regional levels of noradrenaline in the brain by more than 75%, and decreased the concentration of endogenous DA in microdialysates of the caudate nucleus and nucleus accumbens by 52% and 28%, respectively. Results support the hypothesis that central noradrenergic mechanisms facilitate nigrostriatal and mesolimbic dopamine transmission in vivo.

摘要

用去甲肾上腺素能神经毒素DSP-4对大鼠进行预处理，可使大脑中去甲肾上腺素的区域水平选择性降低超过75%，并使尾状核和伏隔核微透析液中内源性多巴胺的浓度分别降低52%和28%。结果支持以下假设：中枢去甲肾上腺素能机制在体内促进黑质纹状体和中脑边缘多巴胺传递。

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