肾上腺素能投射至中脑多巴胺系统的特异性及影响
Specificity and impact of adrenergic projections to the midbrain dopamine system.
作者信息
Mejias-Aponte Carlos A
机构信息
National Institute on Drug Abuse Histology Core, Neuronal Networks Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Biomedical Research Center, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA.
出版信息
Brain Res. 2016 Jun 15;1641(Pt B):258-73. doi: 10.1016/j.brainres.2016.01.036. Epub 2016 Jan 26.
Abstract
Dopamine (DA) is a neuromodulator that regulates different brain circuits involved in cognitive functions, motor coordination, and emotions. Dysregulation of DA is associated with many neurological and psychiatric disorders such as Parkinson's disease and substance abuse. Several lines of research have shown that the midbrain DA system is regulated by the central adrenergic system. This review focuses on adrenergic interactions with midbrain DA neurons. It discusses the current neuroanatomy including source of adrenergic innervation, type of synapses, and adrenoceptors expression. It also discusses adrenergic regulation of DA cell activity and neurotransmitter release. Finally, it reviews several neurological and psychiatric disorders where changes in adrenergic system are associated with dysregulation of the midbrain DA system. This article is part of a Special Issue entitled SI: Noradrenergic System.
摘要
多巴胺（DA）是一种神经调质，可调节参与认知功能、运动协调和情绪的不同脑回路。多巴胺调节异常与许多神经和精神疾病有关，如帕金森病和药物滥用。多项研究表明，中脑多巴胺系统受中枢肾上腺素能系统调节。本综述重点关注肾上腺素能与中脑多巴胺神经元的相互作用。它讨论了当前的神经解剖学，包括肾上腺素能神经支配的来源、突触类型和肾上腺素能受体表达。它还讨论了多巴胺能细胞活动和神经递质释放的肾上腺素能调节。最后，它综述了几种神经和精神疾病，其中肾上腺素能系统的变化与中脑多巴胺系统的调节异常有关。本文是名为“SI：去甲肾上腺素能系统”的特刊的一部分。
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