Iyer P V, Leong A S
Division of Tissue Pathology, Institute of Medical & Veterinary Science, Adelaide, South Australia.
J Cutan Pathol. 1992 Feb;19(1):34-9. doi: 10.1111/j.1600-0560.1992.tb01556.x.
Thirty cases of poorly differentiated carcinomas of the skin were examined for the expression of vimentin. All cases expressed cytokeratins; in addition, 12 cases were positive for vimentin. These were all non-reactive with antibodies to S100 protein, HMB45 and desmin. The finding of vimentin in poorly differentiated squamous cell carcinomas underscores the need for caution in the use of immunohistochemical stains for tumor typing. Cutaneous squamous cell carcinomas are an addition to the list of epithelial tumors which are known to coexpress vimentin intermediate filaments. Other carcinomas which consistently express vimentin include those of renal, endometrial, thyroid, pulmonary, ovarian, salivary gland, adrenal and more recently, those of breast and prostatic origin.
对30例皮肤低分化癌进行波形蛋白表达检测。所有病例均表达细胞角蛋白；此外，12例波形蛋白呈阳性。这些病例均与抗S100蛋白、HMB45和结蛋白抗体无反应。在低分化鳞状细胞癌中发现波形蛋白强调了在使用免疫组化染色进行肿瘤分型时需谨慎。皮肤鳞状细胞癌是已知共表达波形蛋白中间丝的上皮性肿瘤列表中的新增成员。其他持续表达波形蛋白的癌包括肾癌、子宫内膜癌、甲状腺癌、肺癌、卵巢癌、唾液腺癌、肾上腺癌，以及最近发现的乳腺癌和前列腺癌。
