NORTHOVER B J, SUBRAMANIAN G
Br J Pharmacol Chemother. 1961 Apr;16(2):163-9. doi: 10.1111/j.1476-5381.1961.tb00309.x.
The swelling and capillary hyperpermeability of the mouse foot in response to an injection of formaldehyde, and the increased capillary permeability to an intradermal injection of histamine, have been investigated. Cortisone, mepyramine and sodium salicylate were effective in reducing histamine-induced inflammation, sodium salicylate being less active in the adrenalectomized animal. In formaldehyde-induced inflammation, however, cortisone was ineffective whereas sodium salicylate was effective in the intact mouse, but not in the adrenalectomized animal. Certain aryloxypropionates and anti-esterases were also active in reducing the severity of the formaldehyde-induced inflammation.
已经研究了小鼠足部对甲醛注射的肿胀和毛细血管通透性增加，以及对皮内注射组胺的毛细血管通透性增加。可的松、甲氧苄胺嘧啶和水杨酸钠对减轻组胺引起的炎症有效，水杨酸钠在肾上腺切除的动物中活性较低。然而，在甲醛诱导的炎症中，可的松无效，而水杨酸钠在完整小鼠中有效，但在肾上腺切除的动物中无效。某些芳氧基丙酸酯和抗酯酶在减轻甲醛诱导的炎症严重程度方面也有活性。
